The macro-regional dimension in S3 provides a wider choice of combinations of actors, areas and expertise for strategic transnational R&I partnerships in the relevant S3 priority domains. MRS aim bringing together initiatives in different sectors which represent key challenges of the strategy, such as saving the sea or increasing prosperity. The challenges are connected to a wide range of policies which are organised in policy areas or priority areas (PA). Almost all strategies address wellness and prosperity of the region through research and innovation, which is an important policy area for macro-regional cooperation: in EUBSR – PA Innovation; in EUSDR – PA Knowledge Society; in EUSALP – PA Economic Growth and Innovation. These policy areas coordinated by the National Coordinators (NCs) are the core strategic bodies gathering actors for macro-regional collaboration in R&I and smart specialisation.