Smart Specialisation (S3) has been designed as a methodology for knowledge-based economic development agenda. However, the accumulated experience of EU Member States and countries worldwide adopting this approach shows that the priorities and projects chosen in the participative bottom-up processes contribute to a lot of the SDGs and their targets. Having this in mind, the Joint Research Centre of the European Commission joined forces with the United Nation's Inter-Agency Task Team on Science, Technology and Innovation Roadmaps for Sustainable Development Goals and decided to adapt S3 to better contribute to SDGs. The pilot methodology is presently tried in Serbia, one of 5 countries taking part in the Global Pilot Programme for STI Roadmaps for SDGs. See below for main steps and achievements so far.