In the design and implementation of policy, Paul Romer (2000) proposed a useful distinction between goals and programmes. Goals should be objectives for which there is a broad base of intellectual and political support. In contrast to a goal, a programme is a specific policy proposal that seeks to move the system toward a specific goal. A variety of programmes could be tried, including ones where there is some uncertainty about whether they will succeed. If the evidence shows that they do not work, they can be modified or stopped. This policy brief aims at giving an operational content to the concept of smart specialisation. Starting with the identification of the sequence of programmes that need to be designed and implemented as key components of the policy process, we will proceed further to address very practical issues of implementation.